What treatment has been shown to significantly improve the likelihood of preventing recurrent C. difficile infections (CDIs)?

• A. Fecal transplants
• B. Vancomycin
• C. Metronidazole
• D. Probiotics

Answer: (A)

Restoring a healthy gut microbial community after antibiotic disruption is the key to preventing recurrent C. difficile infections. Fecal microbiota transplantation achieves this by transferring diverse donor bacteria into the patient, reestablishing the normal microbiome and the gut’s natural resistance to C. difficile. With this rebalanced ecosystem, the chances of a relapse drop significantly, and cure rates for recurrent CDI are substantially higher than with continued antibiotic therapy. In contrast, vancomycin and metronidazole target the active infection but don’t rebuild the microbiome in a durable way, so recurrence remains a common problem after treatment. Probiotics may help in some cases, but the evidence is inconsistent and typically not as strong as FMT for preventing recurrence.