What is the goal of fecal microbiota transplantation in managing recurrent C. difficile infections?

• A. Restore healthy gut flora and reduce recurrence
• B. Eliminate all bacteria from the gut
• C. Increase antibiotic prophylaxis
• D. Replace the immune system

Answer: (A)

The goal of fecal microbiota transplantation is to reestablish a healthy, diverse gut microbial community so the microbiome can outcompete and suppress C. difficile, reducing the chance of recurrence. In recurrent CDI, the gut flora has been disrupted by antibiotics, creating an environment where C. difficile can thrive. Introducing donor microbes restores microbial diversity and colonization resistance, helps rejoin metabolic networks, and strengthens the gut barrier, making it harder for C. difficile to grow and produce toxins. It’s not about eradicating all bacteria, increasing antibiotics, or replacing the immune system; it’s about rebuilding a balanced ecosystem that can keep harm from returning.