An unvaccinated HCW exposed to HBV and given HBV immunoglobulin. What vaccination recommendation should the IP make for post‑exposure vaccination?

• A. The HCW should be encouraged to take all three doses of the HBV vaccination series.
• B. Do not vaccinate and monitor only for signs of infection.
• C. Begin a yearly influenza vaccination instead.
• D. Only give a booster if exposure recurs in the future

Answer: (A)

Post‑exposure management for hepatitis B in someone who is unvaccinated relies on both immediate protection and long‑term immunity. HBIG gives rapid, short‑term antibodies to help prevent infection right after exposure, but it won’t create lasting protection. To establish durable immunity, start the hepatitis B vaccination series as soon as possible and complete all three doses on schedule (first dose now, second dose about one month later, third dose about six months after the first). This combination reduces the risk of both acute and chronic HBV infection. Other options don’t provide the needed active immunization after exposure, so completing the three‑dose series is the best course.